Cobalt complexes, process for preparation and use thereof
AssigneeCouncil of Scientific and Industrial Research
InventorsSubashchandrabose CHINNATHAMBI, Ekambaram BALARAMAN, Nalini Vijay GORANTLA, Siba Prasad MIDYA
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Abstract
The present invention discloses a cobalt compound of formula (I), a process for the preparation and use thereof. The present invention further relates to a pharmaceutical composition and a method inhibition of Tau Aggregation in a subject in need thereof using compound of formula (I).
Claims10
A cobalt complex compound represented by the general formula (I),
- Wherein, X is selected from the group consisting of halides;
- pseudohalides;
- anionic ligands selected from CN−, H−, RS−, RO−;
- R=R1 or R ≠R1 and Both R and R1 are same or different, straight or branched and represents independently of each other hydrogen, or (un)substituted or substituted alkyl, alkenyl or alkynyl;
- or (un)substituted or substituted aryl, heteroalkyl, heteroaryl, arylalkyl, heteroarylalkyl;
- (un) substituted or substituted cycloalkyls, cycloalkenyl or cycloalkynyl;
- azo, amino, halo, nitro, cyano, hydroxyl, carbonyl, thiocarbonyl, carboxylic, ester, alkoxy, alkylamino, arylaminocarbamide, carbamate, hydrazine, sulfonyl, sulphide, thioether, sulphonamide, phosphates
- R2 represents hydrogen, or (un)substituted or substituted alkyl, alkenyl or alkynyl;
- or (un)substituted or substituted aryl, heteroalkyl, heteroaryl, arylalkyl, heteroarylalkyl;
- (un) substituted or substituted cycloalkyls, cycloalkenyl or cycloalkynyl;
- azo, amino, halo, nitro, cyano, hydroxyl, carbonyl, thiocarbonyl, carboxylic, ester, alkoxy, alkylamino, arylaminocarbamide, carbamate, hydrazine, sulfonyl, sulphide, thioether, sulphonamide, phosphates.
A process for the synthesis of compounds of formula (I) comprising the steps of:
- a) Adding a solution of 2,6-bis(bromomethyl)pyridine in acetonitrile to a solution of amine and base in solvent followed by stirring at a temperature in the range of 80 to 90° C. for the period in the range of 14 to 16 hours to afford NNN-Ligand;
- b) Adding a solution of Cobalt halo hexahydrate in solvent to a solution of NNN-Ligand of step (a) in solvent with stirring for 3 to 4 hours at the temperature range of 25 to 30° C. to afford the desired product of formula (I).
A process for the selective hydrogenation of alkenes or alkynes in the presence of cobalt compound of formula (I) as catalysts comprises mixing alkyne/alkene, amino-borane, cobalt complex and methanol followed by stirring for the period in the range of 10 to 14 h at a temperature range of 50 to 80° C. to obtain the desired alkene/alkane.
Dependencies are inferred from the claim text.