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US 2020/0215001 A1Published application
Compounds, compositions and methods for treating oxidative dna damage disorders
AssigneeIndiana University Research and Technology Corporation
InventorsMark R. Kelley, Michael R. Vasko
Life of this patent
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Abstract
Compounds, compositions, and formulations, and accompanying methods useful for treating disorders arising from oxidative DNA damage, including oxidative DNA damage resulting from ionizing radiation or other therapy are described herein.
Claims20
A compound for preventing or treating neuronal damage in a host animal, the compound having the formula
- or a pharmaceutically acceptable salt thereof, wherein:
- RA represents a fused aryl ring that is optionally substituted;
- R is alkoxy, heteroalkoxy cycloalkoxy, or cycloheteroalkoxy, each of which is optionally substituted;
- X is alkylene, alkenylene, or alkynylene, each of which is optionally substituted;
- and
- Y forms a carboxylic acid, ester, or amide.
3 more elements
Dependencies are inferred from the claim text.