Nanoparticle arsenic-platinum compositions
AssigneeNorthwestern University
InventorsThomas V. O'Halloran, Haimei Chen, Andrew Mazar
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Abstract
The present invention relates to nanoparticle encapsulated arsenic and platinum compositions and methods of use thereof. In particular, the present invention provides co-encapsulation of active forms of arsenic and platinum drugs into liposomes, and methods of using such compositions for the diagnosis and treatment of cancer.
Claims20
A composition comprising a liposomal nanoparticle, wherein said liposomal nanoparticle encapsulates therapeutically effective amounts of a platinum-containing compound and an arsenic-containing compound.
A composition comprising particles having the molecular formula:
- [(X1X2X3X4)Pt]n[(Y1Y2Y3Y4)As]m
- or
- [(X1X2X3X4)Pt]n[(Y1Y2Y3)As]m
- wherein X=O, OH, OH2, N, NH2, NH3, S, SH, Cl, Br, F, P, Se, SeH, an amino carrier ligand, a leaving group, or an R group;
- wherein Y=O, OH, OH2, N, NH2, NH3, S, SH, Cl, Br, F, P, Se, SeH, As, an amino carrier ligand, a leaving group, or an R group;
- wherein R comprises an alkyl group or an alkylidene group;
- wherein n is 10 or less;
- wherein m is 10 or less;
- wherein X is optionally bound to additional substituents;
- and wherein Y is optionally bound to additional substituents.
A method for making a pharmaceutical preparation comprising:
- a) providing:
- i) a lipid composition;
- ii) a platinum-containing compound;
- and
- iii) an arsenic-containing compound;
- b) combining said lipid composition and said platinum-containing compound under conditions such that said lipid compositions forms liposomes, wherein said liposomes encapsulate said platinum-containing compound;
- and
- c) combining said liposomes and said arsenic-containing compound under conditions such that said arsenic-containing compound is co-encapsulated with said platinum containing compound within said liposomes.
Dependencies are inferred from the claim text.