Systems and methods for combining clinical goals with knowledge based dose prediction in treatment planning

A treatment planning method, comprising:

• obtaining a model definition by a modeler, wherein the model definition comprises a first quality metric of a first clinical goal;
• obtaining, by a model trainer, a set of existing treatment plans following desired clinical practice;
• performing, by the model trainer, model training to obtain a trained model based on the existing treatment plans and the first quality metric of the first clinical goal;
• generating, by an objective generator, a cost function based on the trained model;
• and
• determining a treatment plan based on the cost function.

A product having a non-transitory medium storing a set of instructions, an execution of which causes a treatment planning method to be performed, the treatment planning method comprising:

• obtaining a model definition by a modeler, wherein the model definition comprises a first quality metric of a first clinical goal;
• obtaining, by a model trainer, a set of existing treatment plans following desired clinical practice;
• performing, by the model trainer, model training to obtain a trained model based on the existing treatment plans and the first quality metric of the first clinical goal;
• generating, by an objective generator, a cost function based on the trained model;
• and
• determining a treatment plan based on the cost function.