Antithrombogenic hollow fiber membranes and filters
AssigneeInterface Biologics, Inc.
InventorsSanjoy MULLICK, Weilun CHANG, Hanje CHEN, Mark A. STEEDMAN, Roseita ESFAND
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Abstract
The invention relates to extracorporeal blood circuits, and components thereof (e.g., hollow fiber membranes, potted bundles, and blood tubing), including 0.005% to 10% (w/w) surface modifying macromolecule. The extracorporeal blood circuits have an antithrombogenic surface and can be used in hemofiltration, hemodialysis, hemodiafiltration, hemoconcentration, blood oxygenation, and related uses.
Claims8
A hollow fiber membrane, said hollow fiber membrane comprising a base polymer admixed with from 0.005% to 10% (w/w) surface modifying macromolecule, wherein said hollow fiber membrane is antithrombogenic when contacted with blood.
The hollow fiber membrane of claim 2, wherein the thrombi deposition on said surface said hollow fiber membrane is reduced by at least 10% when contacted with blood, wherein said hollow fiber membrane has an operating pressure after 4 hours of use that is reduced by at least 10%, or wherein said hollow fiber membrane reduces adverse advents in a subject receiving blood passing through said hollow fiber membrane.
Dependencies are inferred from the claim text.