Preservative containing compositions
AssigneeJohnson & Johnson Consumer Inc.
InventorsMingqi Bai, Kenneth T. Holeva
Life of this patent
Estimating the term…
Abstract
The present invention relates to compositions providing improved preservative efficacy. The present invention further relates to polyquaternium compound containing compositions having improved the antifungal activity. In certain embodiments, the present invention relates to ophthalmic compositions comprising a polyquaternium compound, a polyol or combination of polyols, borate compound, and an antimicrobial mixture comprising electrolytes and nutrients.
Claims38
A composition, comprising:
- a) from about 0.0005% w/v to about 0.1000% w/v, of the total composition, of a polyquaternium compound;
- b) optionally, from about 0.2% w/v to about 2.0% w/v, of the total composition, of an amount of a polyol or combination polyols;
- c) from about 0.02% w/v to about 1.5% w/v, of the total composition, of a borate;
- and
- e) an antimicrobial mixture comprising:
- iii. one or more nutrients;
- and
- iv. optionally, one or more electrolytes
- such that:
- a. the total nutrient concentration, in the total composition, is from about 1.0 mMol/L to about 4.0 mMol/L of the composition;
- and
- b. when present, the total electrolyte concentration, in the total composition, is from about 20.0 mMol/L to about 80.0 mMol/L of the composition.
A method for improving overall preservative efficacy of a liquid composition, comprising the step of combining:
- a) from about 0.0005% w/v to about 0.1000% w/v, of the total composition, of a polyquaternium compound;
- b) optionally, from about 0.2% w/v to about 2.0% w/v, of the total composition, of an amount of a polyol or combination polyols;
- c) from about 0.02% w/v to about 1.5% w/v, of the total composition, of a borate;
- and
- d) an antimicrobial mixture comprising:
- i. one or more nutrients;
- and
- ii. optionally, one or more electrolytes
- such that:
- a. the total nutrient concentration, in the total composition, is from about 1.0 mMol/L to about 4.0 mMol/L of the composition;
- and
- c. when present, the total electrolyte concentration, in the total composition, is from about 20.0 mMol/L to about 80.0 mMol/L of the composition.
A method for improving antifungal activity of a liquid composition, comprising the step of combining:
- a) from about 0.0005% w/v to about 0.1000% w/v, of the total composition, of a polyquaternium compound;
- b) optionally, from about 0.2% w/v to about 2.0% w/v, of the total composition, of an amount of a polyol or combination polyols;
- c) from about 0.02% w/v to about 1.5% w/v, of the total composition, of a borate;
- and
- d) an antimicrobial mixture comprising:
- i. one or more nutrients;
- and
- ii. optionally, one or more electrolytes
- such that:
- a. the total nutrient concentration, in the total composition, is from about 1.0 mMol/L to about 4.0 mMol/L of the composition;
- and
- c. when present, the total electrolyte concentration, in the total composition, is from about 20.0 mMol/L to about 80.0 mMol/L of the composition.
A composition comprising the following formulation:
- a. from about 0.01% w/v to about 0.2% w/v vasoconstictor;
- b. from about 0.0015% w/v to about 0.0036% w/v polyquaternium 42;
- c. from about 0.2% w/v to about 1.2% w/v polyethylene glycol 400;
- d. from about 0.2% w/v to about 1.3% w/v glycerin;
- e. from about 0.004% w/v to about 0.6% w/v borate;
- f. from about 0.05% w/v to about 0.2% w/v lactate or pharmaceutically acceptable salt thereof;
- g. from about 0.003% w/v to about 0.4% w/v, optionally 0.003% to about 0.04% w/v glucose;
- h. from about 0% w/v to about 2.5% w/v hypromellose;
- and
- i. water.
A composition, comprising:
- a) from about 0.0005% w/v (weight to volume) to about 0.1000% w/v, of the total composition, of a polyquaternium compound;
- and
- b) from about 0.002% w/v to about 1% w/v, of saccharide selected from monosaccharide, disaccharide, isomers thereof or mixtures thereof.
A method for preventing the growth of or reducing the number of viable fungal organisms in an environment or medium, comprising the steps of;
- a.) preparing a composition comprising:
- i) from about 0.0005% w/v (weight to volume) to about 0.1000% w/v, of the total composition, of a polyquaternium compound;
- and
- ii) from about 0.002% w/v to about 1% w/v, of saccharide selected from monosaccharide, disaccharide, isomers thereof or mixtures thereof;
- and
- b.) administering the composition to the environment or medium.
Dependencies are inferred from the claim text.