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US 2020/0206352 A1Published application
Optimal osmotic range for a drug-containing solution suitable for lymphatic delivery
AssigneeTohoku University
InventorsTetsuya KODAMA, Shiro MORI
Life of this patent
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Abstract
Provided is an optimal intralymphatic preparation containing agents such as a drug, a cell, or a nucleic acid for use in a lymphatic drug delivery system. A drug-containing liquid preparation for delivering a chemical to a target lymph node by a lymphatic drug delivery system, wherein the liquid has an osmotic pressure of 700 to 2,700 kPa.
Claims14
1:
- An intralymphatic liquid preparation, comprising a drug, wherein an osmotic pressure of the liquid ranges from 700 to 2,700 kPa.
2:
- The preparation according to claim 1, wherein the osmotic pressure of the liquid ranges from 900 to 2,700 kPa.
3:
- The preparation according to claim 1, wherein the osmotic pressure of the liquid ranges from 700 to 2,400 kPa.
4:
- The preparation according to claim 1, wherein the osmotic pressure of the liquid ranges from 950 to 2,000 kPa.
5:
- The preparation according to claim 1, wherein a viscosity of the liquid ranges from 0.5 to 20 mPa·s.
6:
- The preparation according to claim 1, wherein a viscosity of the liquid ranges from 1.0 to 15 mPa·s.
7:
- The preparation according to claim 1, wherein the preparation further comprises a nonionic surfactant.
8:
- The preparation according to claim 7, wherein the nonionic surfactant is a polyoxyethylene sorbitan fatty acid ester.
9:
- The preparation according to claim 8, wherein the polyoxyethylene sorbitan fatty acid ester is polyoxyethylene sorbitan oleate.
10:
- The preparation according to claim 1, wherein the drug is a pharmaceutically active substance, a nucleic acid molecule container or a cultured cell.
11:
- The preparation according to claim 1, wherein the drug is an anticancer drug.
12:
- A lymphatic drug delivery method, comprising delivering a drug to a target with the intralymphatic liquid preparation according to claim 1.
13:
- The method according to claim 12, wherein the drug is a pharmaceutically active substance, a nucleic acid molecule container or a cultured cell.
14:
- The method according to claim 12, wherein the drug is an anticancer drug.