Method of indirect immunization of human ovarian cancer patients through selection of xenogeneic immunoglobulin fc portions
AssigneeOncoquest Inc.
InventorsRagupathy Madiyalakan, Christopher F. Nicodemus
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Abstract
The present document describes a method for therapeutic indirect immunization of an optimally debulked human ovarian cancer patient having a CA125 antigen level in the blood above normal levels, comprising administering to said human patient a monoclonal antibody specific to CA125 antigen having at least a xenogeneic Fc region; an immune complex formed between CA125 antigen and said monoclonal antibody having at least a xenogeneic Fc region; or a combination thereof.
Claims25
A method for therapeutic indirect immunization of an optimally debulked human ovarian cancer patient having a CA125 antigen level in the blood above normal levels, comprising administering to the human patient:
- (a) a monoclonal antibody specific to CA125 antigen having at least a xenogeneic Fc region;
- (b) an immune complex formed between CA125 antigen and the monoclonal antibody having at least a xenogeneic Fc region;
- or
- (c) a combination thereof.
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Dependencies are inferred from the claim text.