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AssigneeCancer Advances Inc.
InventorsLynda Sutton, Jill P. Smith, Nicholas Osborne, Brian E. Huber, Allen Cato
Estimating the term…
Provided are methods for sensitizing gastrin-associated tumors and/or cancers in subjects to inducers of humoral and cellular immune responses. In some embodiments, the methods relate to administering compositions that have anti-gastrin antibodies, gastrin peptides, and/or nucleic acids that inhibit expression of gastrin gene products to subjects. Also provided are methods for preventing, reducing, and/or eliminating the formation of fibroses associated with tumors and/or cancers, and methods for treating gastrin-associated tumors and/or cancers that include administering to subjects in need thereof a first agent that provides and/or induces an anti-gastrin humoral or cellular immune response in the subject and a second agent that includes one or more stimulators of cellular immune responses against the tumors and/or cancers.
A pharmaceutical composition comprising (i) a first agent that induces and/or provides an active and/or a passive humoral immune response against a gastrin peptide and/or a CCK-B receptor;
A method for treating a gastrin-associated tumor or cancer in a subject, the method comprising administering to the subject an effective amount of a composition that comprises (i) a first agent that induces and/or provides an active and/or a passive humoral immune response against a gastrin peptide and/or a CCK-B receptor;
A method for treating a gastrin-associated tumor and/or cancer, the method comprising administering to a subject in need thereof a first agent that directly or indirectly inhibits one or more biological activities of gastrin in the tumor and/or cancer and a second agent comprising a stimulator of a cellular immune response against the tumor and/or the cancer.
A method for inhibiting growth of a gastrin-associated tumor and/or cancer in a subject, the method comprising administering to the subject a composition that comprises a first agent comprising a gastrin immunogen, one or more anti-gastrin antibodies, one or more anti-CCK-B receptor antibodies, or any combination thereof;
A method for inducing and/or enhancing a cellular immune response against a gastrin-associated tumor or cancer in a subject, the method comprising administering to a subject that has a gastrin-associated tumor or cancer an effective amount of a composition comprising an agent that reduces or inhibits gastrin signaling via CCK-B receptors present on a gastrin-associated tumor or cancer.
A method for sensitizing a tumor and/or a cancer associated with gastrin and/or CCK-B receptor signaling in a subject to an inducer of a cellular immune response directed against the tumor and/or cancer, the method comprising administering to the subject a composition comprising:
A method for preventing, reducing, and/or eliminating formation of fibrosis associated with a tumor and/or a cancer, the method comprising contacting cells of the tumor and/or the cancer with an agent that directly or indirectly inhibits one or more biological activities of gastrin in the tumor and/or cancer.
Use of a composition comprising an immune checkpoint inhibitor and a gastrin immunogen to treat a gastrin-associated tumor or cancer.
Use of a composition comprising an immune checkpoint inhibitor and a gastrin immunogen for the preparation of a medicament to treat a gastrin-associated tumor or cancer.
Dependencies are inferred from the claim text.