Manipulation of eif3 to modulate repeat associated non-atg (ran) translation
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsLaura Ranum, Fatma Ayhan, Tao Zu
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Abstract
Methods and compositions for modulating repeat non-ATG protein (RAN protein) translation are provided. In some aspects, the disclosure relates to methods for treating a subject having a disease associated with RAN protein translation by administering the subject a modulator of eIF3 or an eIF3 subunit, or an antibody that bind to a RAN protein.
Claims37
A method of modulating repeat non-ATG protein (RAN protein) translation, the method comprising contacting a cell expressing a repeat non-ATG protein (RAN protein) with an effective amount of a eukaryotic initiation factor 3 (eIF3) modulating agent.
A method of treating a disease associated with repeat non-ATG protein (RAN protein) translation, the method comprising administering to a subject expressing a repeat non-ATG protein (RAN protein) an effective amount of a eukaryotic initiation factor 3 (eIF3) modulating agent.
The method of any one of claims 17 to 33, wherein the subject is a human subject.
A method of treating a disease associated with repeat non-ATG protein (RAN protein) translation, the method comprising administering to a subject expressing a repeat non-ATG protein (RAN protein) an effective amount of an antibody that binds specifically to a RAN repeat expansion, or an antibody that binds specifically to a unique region of a RAN protein that is C-terminal to the repeat expansion.
Dependencies are inferred from the claim text.