Composition and uses thereof

A composition comprising compounds selected from the group consisting of withaferin A, sulforaphane, berteroin, genipin, berberine, resveratrol, emodin, piperine, spermidine, beta-hydroxybutyric acid, silybin, forskolin, indole-3-carbinol and cannabidiol.

A composition comprising two or more compounds or extracts selected from withaferin A (derived from Withania somnifera), curcumin (derived from Curcuma longa), and piperine (derived from Piper nigrum).

The composition of any one of claims1 to 8, wherein the composition is formulated for oral administration.

A composition comprising one or more natural products selected from the group consisting of compounds that can be isolated from cruciferous vegetables, compounds that can be isolated from plants of the genera Withania, Brassica, Armoracia, Barbarea, Diplotaxis, Eruca, Lepidium, Nasturtium, Raphanus, Wasabia, Curcuma, Piper, Gardenia, Berberis, Silybum, Plectranthus, Vitis, Vaccinum, Rubus, Rheum, or Cannabis, and compounds that can be isolated from rhubarb, buckthorn, Japanese knotweed, black pepper, and wheat germ;

• and
• one or more omega-3 fatty acids.

The composition of any one of 11 to 40, wherein the composition is formulated for oral administration.

Use of one or more natural products selected from the group consisting of withaferin A, sulforaphane, berteroin, genipin, berberine, resveratrol, emodin, piperine, spermidine, beta-hydroxybutyric acid, silybin, forskolin, indole-3-carbinol and cannabidiol, in the manufacture of a medicament for protecting a subject from sterile inflammation.

Use of two or more compounds or extracts selected from withaferin A (derived from Withania somnifera), curcumin (derived from Curcuma longa), and piperine (derived from Piper nigrum), in the manufacture of a medicament for protecting a subject from sterile inflammation.

Use of one or more natural products selected from the group consisting of withaferin A, sulforaphane, berteroin, genipin, berberine, resveratrol, emodin, piperine, spermidine, beta-hydroxybutyric acid, silybin, forskolin, indole-3-carbinol and cannabidiol, in the manufacture of a medicament for treating and/or preventing a condition associated with sterile inflammation.

Use of two or more compounds or extracts selected from withaferin A (derived from Withania somnifera), curcumin (derived from Curcuma longa), and piperine (derived from Piper nigrum), in the manufacture of a medicament for treating and/or preventing a condition associated with sterile inflammation.

Use of one or more natural products selected from the group consisting of withaferin A, sulforaphane, berteroin, genipin, berberine, resveratrol, emodin, piperine, spermidine, beta-hydroxybutyric acid, silybin, forskolin, indole-3-carbinol and cannabidiol, for protecting a subject from sterile inflammation.

Use of two or more compounds or extracts selected from withaferin A (derived from Withania somnifera), curcumin (derived from Curcuma longa), and piperine (derived from Piper nigrum), for protecting a subject from sterile inflammation.

Use of one or more natural products selected from the group consisting of withaferin A, sulforaphane, berteroin, genipin, berberine, resveratrol, emodin, piperine, spermidine, beta-hydroxybutyric acid, silybin, forskolin, indole-3-carbinol and cannabidiol, for treating and/or preventing a condition associated with sterile inflammation.

Use of two or more compounds or extracts selected from withaferin A (derived from Withania somnifera), curcumin (derived from Curcuma longa), and piperine (derived from Piper nigrum), for treating and/or preventing a condition associated with sterile inflammation.