Inhibition of aminocylase 3 (aa3) in the treatment of cancer
AssigneeThe Regents of the University of California
InventorsIra B KURTZ, Alexander PUSHKIN, Kirill B. TSIRULNIKOV
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Abstract
The current methods and compositions provide for therapeutic approaches to treating hepatocellular carcinoma (HCC) and other types of cancer including, for example, pancreatic and colon cancer. Accordingly, certain aspects of the disclosure relates to methods and compositions for treating HCC, pancreatic and colon cancer using one or more small molecule inhibitors disclosed herein. In certain embodiments, the small molecule inhibitor is a benzothiazine, a sulfonamide, a thiazolidinone or other chemical compound.
Claims89
A method of treating hepatocellular carcinoma (HCC), pancreatic cancer or colon cancer in a subject comprising administering to the subject an effective amount of a composition comprising an AA3 inhibitor.
A method of reducing or inhibiting hepatocellular carcinoma (HCC) growth or proliferation in a subject comprising administering to the subject an effective amount of a composition comprising an AA3 inhibitor.
A pharmaceutical composition comprising a benzothiazinone that is 2-Phenyl-4H-1,3-benzothiazin-4-one or 2-Phenyl-1,2-benzoselenazol-3(2H)-one, or a derivative, analog, or salt thereof.
A pharmaceutical composition comprising 6-Chloro-3-(3-fluorobenzoyl)-4H-chromen-4-one and 7-Diethylamino-3-(5-pyridin-4-yl-[1,3,4]oxadiazol-2-yl)-chromen-2-one, 4-Methyl-N-(6-methyl-5,6-dihydro-4H-[1,3]thiazolo[4,5-e]indazol-2-yl)-1,3-thiazole-5-carboxamide, N-[(4-Methoxyphenyl)(4-pyridinyl)methyl]-2-methyl-1,3-benzothiazole-6-carboxamide, 2-(1,3-Benzothiazol-2-ylsulfanyl)ethanamine hydrobromide, 3-[2-(Benzylamino)-2-oxoethyl]-1,3-benzothiazol-3-ium bromide, 8-(4-Methoxyphenyl)-9-sulfanyl-5,8-dihydronaphtho[2′,1′:4,5]thieno[2,3-d]pyrimidin-7(6H)-one or {[2-(4-Methoxyphenyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl]sulfanyl}acetic acid, 6-[(2-Bromo-4-thiocyanatophenyl)carbamoyl]-3-cyclohexene-1-carboxylic acid or 6-[(2-Chloro-4-thiocyanatophenyl)carbamoyl]-3-cyclohexene-1-carboxylic acid, 2-[(3-Fluoro-4-methoxybenzyl)sulfanyl]-1-methyl-1H-benzimidazole-5-sulfonamide (Inhibitor 11), 3-Methyl-4-tetrazol-1-yl-N-(2-m-tolyl-ethyl)-benzenesulfonamide, N-(2,3-Dichloro-4-oxo-4H-naphthalen-1-ylidene)-benzenesulfonamide N-[(1E)-2,3,5-Trichloro-4-oxocyclohexa-2,5-dien-1-ylidene]benzenesulfonamide, or 4-Methyl-N′-(4-methylphenyl)benzenesulfonohydrazide, (5Z)-5-(3-Bromo-2-hydroxy-5-nitrobenzylidene)-3-(2,4-dimethylphenyl)-2-thioxo-1,3-thiazolidin-4-one (Inhibitor 3), (5Z)-5-(3-Bromo-2-hydroxy-5-nitrobenzylidene)-3-(3-fluorophenyl)-2-thioxo-1,3-thiazolidin-4-one, (5Z)-5-(3-Bromo-2-hydroxy-5-nitrobenzylidene)-3-(3-methylphenyl)-2-thioxo-1,3-thiazolidin-4-one, or (5E)-5-{[5-(2-Bromophenyl)-2-furyl]methylene}-2-thioxo-1,3-thiazolidin-4-one, 4-Methyl-N-(6-methyl-5,6-dihydro-4H-[1,3]thiazolo[4,5-e]indazol-2-yl)-1,3-thiazole-5-carboxamide, 4-[(4-Methoxybenzoyl)amino]-N-(4-methylphenyl)-1-piperidinecarboxamide, 3-Benzenesulfonyl-1-(4-chloro-phenyl)-3-furan-2-yl-propan-1-one, 1-Benzyl-3-[4-(2-pyridinyl)-1-piperazinyl]-2,5-pyrrolidinedione, N-(3-Cyano-4,5-dimethyl-2-thienyl)-2-[(7-ethyl[1,3]dioxolo[4,5-g]quinolin-6-yl)sulfanyl]acetamide, (5E)-5-(2-Methoxybenzylidene)-1-(1-naphthyl)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione, (4E)-5-Methyl-4-{[(4-nitrophenyl)amino]methylene}-2-phenyl-2,4-dihydro-3H-pyrazole-3-thione, 2-[(E)-(4H-1,2,4-Triazol-4-ylimino)methyl]-1-benzothiophene-3-ol, 2-(4-methylphenyl)-1,2-benzothiazol-3-one, 2-phenyl-1,2-benzoselenazol-3(2H)-one, or 2-(4-ethoxyphenyl)-2-methyl succinic acid, or a derivative, analog, or salt thereof.
Dependencies are inferred from the claim text.