Novel compounds

A method of treating a disorder mediated by inappropriate PI3-kinase activity comprising administering a safe and effective amount of a compound of formula (I):

• wherein
• R1 is 9- or 10-membered bicyclic heteroaryl wherein the 9- or 10-membered bicyclic heteroaryl contains from one to three heteroatoms independently selected from oxygen and nitrogen and is optionally substituted by C3-6cycloalkyl, halo, —CN or —NHSO2R5, or
• pyridinyl optionally substituted by one or two substituents independently selected from C1-6alkyl, —OR6, halo and —NHSO2R7;
• R2 and R3, together with the nitrogen atom to which they are attached, are linked to form a 6- or 7-membered heterocyclyl wherein the 6- or 7-membered heterocyclyl optionally contains an oxygen atom or a further nitrogen atom;
• R4 is methyl;
• R6 is hydrogen or C1-4alkyl;
• and
• R5 and R7 are each independently C1-6alkyl, or phenyl optionally substituted by one or two substituents independently selected from halo;
• or a salt thereof, to a patient in need thereof.