Modulators of alpha-synuclein
AssigneeKainos Medicine, Inc.
InventorsEunhee KIM, Taeik JANG, Boksuk KIM, Changsun YU, Jae Moon LEE, Sungeun YOO, Yeontae CHUNG
Life of this patent
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Abstract
The disclosure provides diagnostic methods and methods for treatment of conditions arising from alpha-synucleopathies. An aminopyrazole compound can be used for treatment of such conditions by lowering the amount of alpha-synuclein in cells of a subject.
Claims11
A method for treating a disease or condition arising from synucleinopathies comprising administering to a subject presenting symptoms of or at risk for said synucleinopathies an effective amount of an inhibitor of FAF1 activity of raising the amount of alpha-synuclein or an effective amount of an inhibitor of the FAF1 activity of regulating the amounts of LC-3 and p62.
A method for treating a disease or condition arising from synucleinopathies comprising administering to a subject presenting symptoms of or at risk for said synucleinopathies an amount of a compound that binds to FAF1 protein that is effective for decreasing the amount of α-synuclein that is phosphorylated at amino acid S129 in cells of said subject.
A method for diagnosing synucleinopathies or assessing risk of synucleinopathies in a subject comprising measuring FAF1 activity or FAF1 level of inhibiting autophagy comprising LC-3 and p62 proteins in cells of a subject, wherein an activity level or protein level of FAF1 is greater than normal people indicating development of synucleinopathies or a risk of the subject developing synucleinopathies.
A method for treating a disease or condition arising from synucleinopathies in a subject comprising administering to a subject who exhibits in cells of said subject FAF1 activity or FAF1 level of inhibiting autophagy comprising LC-3 and p62 proteins in cells of a subject, wherein an activity level or protein level of FAF1 is greater than normal people indicating development of synucleinopathies or a risk of the subject developing synucleinopathies, or an amount of a compound that binds to FAF1 protein that is effective for decreasing the amount of α-synuclein that is phosphorylated at amino acid S129 in cells of said subject.
Dependencies are inferred from the claim text.