Ophthalmic compositions containing a nitric oxide releasing prostamide

An ophthalmic aqueous composition comprising:

• 0.005% w/w to 0.10% w/w hexanoic acid, 6-(nitrooxy)-, (1S,2E)-3-[(1R,2R,3 S,5R)-2-[(2Z)-7-(ethylamino)-7-oxo-2-hepten-1-yl]-3,5-dihydroxycyclopentyl]-1-(2-phenylethyl)-2-propen-1-yl ester;
• 0.5% w/w to 1.5% w/w macrogol 15 hydroxystearate;
• 0.013% w/w to 0.02% w/w benzalkonium chloride;
• 0.03% w/w to 0.07% w/w of an edetate salt;
• sodium phosphate dibasic heptahydrate;
• boric acid;
• and
• water,
• wherein the ophthalmic aqueous composition is a solution having a pH from 5.5 to 6.5, and
• wherein the macrogol 15 hydroxystearate is the only solubilizing agent.