Treatment of diseases associated with hepatic stellate cell activation using ammonia-lowering therapies
AssigneeUCL Business PLC
InventorsRajiv Jalan, Rajeshwar Prosad Mookerjee, Krista Rombouts, Fausto Andreola, Francesco De Chiara, Karen Louise Thomsen
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Abstract
Disclosed herein are methods of preventing, treating, and delaying the onset or progression of diseases associated with hepatic stellate cells (HSCs), such as non-alcoholic fatty liver disease (NAFLD), fibrosis, and liver cancer, using ammonia-lowering therapies.
Claims21
-32. (canceled)
A method of treating or delaying the onset or progression of a disease associated with hepatic stellate cell (HSC) activation, comprising administering one or more ammonia-lowering agents to a subject in need thereof, wherein the ammonia-lowering agent is selected from the group consisting of sodium phenylacetate, sodium phenylbutyrate (NaPBA), sodium benzoate, a laxative, an antibiotic, ornithine in combination with at least one of phenylacetate and phenylbutyrate, and any combinations thereof.
A method of preventing non-alcoholic fatty liver disease (NAFLD), comprising administering one or more ammonia-lowering agents to a subject in need thereof, wherein the ammonia-lowering agent is selected from the group consisting of sodium phenylacetate, sodium phenylbutyrate (NaPBA), sodium benzoate, a laxative, an antibiotic, ornithine in combination with at least one of phenylacetate and phenylbutyrate, and any combinations thereof.
Dependencies are inferred from the claim text.