Colonic drug delivery formulation
AssigneeUniversity College London
InventorsAbdul Basit, Valentine Ibekwe
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Abstract
A delayed release coating includes a mixture of a first material selected from starch; amylose; amylopectin; chitosan; chondroitin sulfate; cyclodextrin; dextran; pullulan; carrageenan; scleroglucan; chitin; curdulan and levan, and a second material which has a pH threshold at about pH 5 or above. The delayed release coating is used to target release of a drug from a core to the intestine, particularly the colon.
Claims32
A delayed release drug formulation suitable for delivering a drug to the colon of a subject, comprising a particle with a core and a coating for the core, the core comprising a drug and the coating comprising a mixture of a first material which is susceptible to attack by colonic bacteria and a second material which is a film-forming polymeric material having a pH threshold at about pH 6.5 or above, wherein the first material comprises a polysaccharide selected from the group consisting of starch having no more than 75 wt % amylose;
- amylopectin;
- chitosan;
- chondroitin sulfate;
- cyclodextrin;
- dextran;
- pullulan;
- and carrageenan;
- wherein a ratio of the first material to the second material in the mixture is from 30:70 to 99:1;
- and wherein release of the drug is delayed until after the colon of subject.
Dependencies are inferred from the claim text.