US 2020/0205667 A1 · SERS-ACTIVE OPTO-FLUIDIC PHOTONIC CRYSTAL FIBER PROBE AS BIOPSY NEEDLE AND OPTOFLUIDIC SENSOR

Abstract

The present application discloses a surface-enhanced Raman scattering (SERS)-active photonic crystal fiber (PCF) probe including a biopsy needle in the PCF probe for integrated sample collection and SERS sensing of one or more analytes comprised in the sample. The PCF comprises solid core and a cladding region surrounding the solid core, wherein the cladding region comprises air holes functionalised by metallic nanoparticles. The application also provides a method for detecting one or more analytes using the PCF probe as well as the use of the PCF probe for the detection of one or more analytes.

Claims23

Dependent claims

A surface-enhanced Raman scattering (SERS)-active photonic crystal fiber (PCF) probe for integrated sample collection and SERS sensing of one or more analytes comprised in the sample, the probe comprising a biopsy needle and a SERS-active PCF integrated into or in communication with the biopsy needle,

wherein the PCF has a longitudinal axis and comprises a solid core extending along the length of the longitudinal axis and a cladding region surrounding the solid core, wherein at least the cladding region comprises one or more air holes extending along the longitudinal axis of the PCF,
wherein the inner surface of the one or more air holes is functionalized by metallic nanoparticles immobilized thereon that enhance Raman scattering, and the one or more air holes are adapted for SERS sensing of the one or more analytes.

Dependencies are inferred from the claim text.

Facts

Application

16/622,882Filed 2 Jul 2018

Priority

SG 10201705412Q30 Jun 2017

Published

2 Jul 2020

Term ends

Not estimatedThe source records don’t support an estimate.

Classification20 codes

A61B 5/0075
Using light, e.g. diagnosis by transillumination, diascopy, fluorescence: by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy,…
A61B 5/1459
Using optical sensors, e.g. spectral photometrical oximeters: invasive, e.g. introduced into the body by a catheter
A61B 5/6848
Mounted on an invasive device: needles
A61B 10/0233
Instruments for taking cell samples or for biopsy: pointed or sharp biopsy instruments

Sers-active opto-fluidic photonic crystal fiber probe as biopsy needle and optofluidic sensor

Life of this patent

Sers-active opto-fluidic photonic crystal fiber probe as biopsy needle and optofluidic sensor

Life of this patent

Abstract

Claims23