Compositions and methods that modulate digestibility in a companion animal

A pet food composition, comprising:

• protein, carbohydrates, fat, fiber, and
• at least 6 distinct metabolites for individually modulating organic matter digestibility, dry matter digestibility, fiber digestibility, energy digestibility, fat digestibility and protein digestibility in a companion animal;
• wherein the metabolite that modulates organic matter digestibility is selected from the group consisting of trigonelline (N′-methylnicotinate), mannose, arachidonate (20:4n6), dihomo-linoleate (20:2n6), docosapentaenoate (n6 DPA;
• 22:5n6), pantothenate, X-09789, dihomo-linolenate (20:3n3), dihomo-linolenate (20:3n6), 3-hydroxybutyrate (BHBA), adrenate (22:4n6), docosapentaenoate (n3 DPA;
• 22:5n3), eicosenoate (20:1n9), eicosenoate (20:1n11), X-11378, alpha linolenate (18:3n3), gamma linolenate (18:3n6), stachydrine, glycerate, gamma-glutamylphenylalanine, X-16975, X-17185, arabitol, creatine, octanoylcarnitine, trans-4-hydroxyproline, X-17010, glycolate (hydroxyacetate), N-acetylornithine, campesterol, oxidized glutathione (GSSG), phenylalanine, oleoyltaurine, arabonate, X-12450, palmitoleate (16:1n7), acetylcarnitine, palmitate (16:0), erythritol, linoleate (18:2n6), stearate (18:0), and mixtures thereof;
• wherein the metabolite that modulates dry matter digestibility is selected from the group consisting of mannose, trigonelline (N′-methylnicotinate), arachidonate (20:4n6), dihomo-linoleate (20:2n6), N-palmitoyl taurine, docosapentaenoate (n6 DPA;
• 22:5n6), X-09789, pantothenate, docosapentaenoate (n3 DPA;
• 22:5n3), X-16975, 3-hydroxybutyrate (BHBA), X-11378, linolenate [alpha or gamma;
• (18:3n3 or 6)], gamma-glutamylphenylalanine, dihomo-linolenate (20:3n3 or n6), eicosenoate (20:1n9 or 11), arabitol, adrenate (22:4n6), X-17185, Glycerate, glutathione (oxidized (GSSG)), mannitol, octanoylcarnitine, N-acetylornithine, X-17010, glycolate (hydroxyacetate), stachydrine, campesterol, palmitoleate (16:1n7), creatine, X-12450, oleoyltaurine, arabonate, trans-4-hydroxyproline, phenylalanine, erythritol, palmitate (16:0), and mixtures thereof;
• wherein the metabolite that modulates energy digestibility is selected from the group consisting of trigonelline (N′-methylnicotinate), mannose, arachidonate (20:4n6), dihomo-linoleate (20:2n6), docosapentaenoate (n6 DPA;
• 22:5n6), N-palmitoyl taurine, betaine, X-09789, pantothenate, adrenate (22:4n6), dihomo-linolenate (20:3n3), dihomo-linolenate (20:3n6), X-11378, glycerate, 3-hydroxybutyrate (BHBA), docosapentaenoate (n3 DPA;
• 22:5n3), stachydrine, X-17185, eicosenoate (20:1n9), eicosenoate (20:1n11), alpha linolenate (18:3n3), gamma linolenate (18:3n6), gamma-glutamylphenylalanine, X-16975, creatine, campesterol, glycolate (hydroxyacetate), X-17010, octanoylcarnitine, N-acetylornithine, trans-4-hydroxyproline, phenylalanine, oxidized glutathione (GSSG), arabitol, mannitol, acetylcarnitine, erythritol, oleoyltaurine, X-12450, palmitoleate (16:1n7), arabonate, palmitate (16:0), docosahexaenoate (DHA;
• 22:6n3), linoleate (18:2n6), stearate (18:0), and mixtures thereof;
• wherein the metabolite that modulates fat digestibility is selected from the group consisting of trigonelline (N′-methylnicotinate), X-09789, arachidonate (20:4n6), mannose, betaine, oxidized glutathione (GSSG), X-11378, dihomo-linoleate (20:2n6), glycerate, campesterol, docosapentaenoate (n6 DPA;
• 22:5n6), glycolate (hydroxyacetate), pantothenate, adrenate (22:4n6), X-17185, N-acetylornithine, gamma-glutamylphenylalanine, octanoylcarnitine, stachydrine, dihomo-linolenate (20:3n3), dihomo-linolenate (20:3n6), docosapentaenoate (n3 DPA;
• 22:5n3), 3-hydroxybutyrate (BHBA), X-17010, X-16975, 15-methylpalmitate (isobar with 2-methylpalmitate), mannitol, citrulline, alpha linolenate (18:3n3), gamma linolenate (18:3n6), phenylalanine, erythritol, arabitol, eicosenoate (20:1n9), eicosenoate (20:1n11), cholate, gamma-glutamylalanine, creatine, 3-dehydrocholate, docosahexaenoate (DHA;
• 22:6n3), trans-4-hydroxyproline, 7-ketodeoxycholate, 12-dehydrocholate, chenodeoxycholate, acetylcarnitine, palmitoleate (16:1n7), and mixtures thereof;
• wherein the metabolite that modulates protein digestibility is selected from the group consisting of trigonelline (N′-methylnicotinate), X-09789, mannose, dihomo-linoleate (20:2n6), docosapentaenoate (n6 DPA;
• 22:5n6), X-11378, trans-4-hydroxyproline, arachidonate (20:4n6), X-17185, betaine, X-15461, N-acetylornithine, creatine, stachydrine, 4-hydroxyphenylacetate, eicosenoate (20:1n9), eicosenoate (20:1n11), campesterol, gamma-glutamylphenylalanine, pantothenate, mannitol, docosapentaenoate (n3 DPA;
• 22:5n3), adrenate (22:4n6), alpha linolenate (18:3n3), gamma linolenate (18:3n6), X-16975, glycerate, phenylalanine, oxidized glutathione (GSSG), palmitoleate (16:1n7), octanoylcarnitine, X-12450, erythritol, 3-hydroxybutyrate (BHBA), 3-(4-hydroxyphenyl)propionate, 1-heptadecanoylglycerophosphocholine, 3-phenylpropionate (hydrocinnamate), oleoyltaurine, and mixtures thereof;
• wherein the metabolite that modulates fiber digestibility is selected from the group consisting of 1-heptadecanoylglycerophosphoethanolamine, 1-palmitoylplasmenylethanolamine, 1-palmitoylglycerol (1-monopalmitin), alpha-tocopherol, ribitol, and mixtures thereof;
• and
• wherein the pet food composition provides at least a 5% increase or at least a 5% decrease in at least one of organic matter digestibility, dry matter digestibility, fiber digestibility, energy digestibility, fat digestibility or protein digestibility in the companion animal upon administration of the pet food to the companion animal.