Class a gpcr-binding compound modifier
AssigneeRiken
InventorsShigeyuki YOKOYAMA, Tetsuya HORI
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Abstract
To provide a novel class-A GPCR antagonist, a production method therefor, or a novel compound that interacts with a Na+-water cluster binding site of a class-A GPCR. Used is a compound or a salt thereof comprising a structure comprising a class-A GPCR-binding compound linked to a functional group that can bind to a Na+-water cluster binding site of the class-A GPCR. Also used is a method for producing a class-A GPCR antagonist, comprising the step of linking one compound with another compound that can bind to a Na+-water cluster binding site of the class-A GPCR.
Claims25
A compound or a salt thereof comprising a structure comprising a class-A GPCR-binding compound linked to a functional group that can bind to a Na+-water cluster binding site of the class-A GPCR.
(canceled)
13-15. (canceled)
20-22. (canceled)
A method for producing a class-A GPCR antagonist, comprising the step of linking one compound with another compound that can bind to a Na+-water cluster binding site of the class-A GPCR.
26-28. (canceled)
A binding molecule that specifically binds to a complex comprising:
- a class-A GPCR;
- and a compound or a salt thereof having a functional group that can bind to a Na+-water cluster binding site of the class-A GPCR.
(canceled)
Dependencies are inferred from the claim text.