Compound used as autophagy regulator, and preparation method therefor and uses thereof

A compound of general formula (I), or pharmaceutically acceptable salts thereof:

• wherein:
• X and Y are each independently selected from the group consisting of O, S, NRa, NOH, and CH2;
• U and V are each independently selected from the group consisting of C, S, SO, and PORa;
• W, Z, and T are each independently selected from the group consisting of O, S, SO, SO2, N, NRa, CO, C, CRa, and CH2;
• m is 0, 1, 2, or 3;
• n is 0, 1, 2, or 3;
• R1 is selected from the group consisting of H, deuterium, C1-6 alkyl, C1-6 hydroxyalkyl, C1-6 haloalkyl, phenyl and substituted phenyl;
• R2 is expressed as -J-K-M-Q, wherein:
• J is NRa, NORa, O, S or
• wherein:
• is a divalent 3-10 membered heterocycloalkyl group containing at least one nitrogen atom or a divalent 3-7 membered heterocycloalkenyl group containing at least one nitrogen atom;
• K is a covalent bond, NRa, CRcRc′ or CRcRc′CRcRc′;
• M is a covalent bond, CRcRc′, a divalent 3-10 membered heterocycloalkyl group, a divalent 3-7 membered heterocycloalkenyl, or a divalent 5-10 membered heteroaryl group,
• Q is H, C1-6 alkyl, C1-6 hydroxyalkyl, —(CH2)p—C(O)Rb, —(CH2)p—C(O)NHRb, —(CH2)p—C(S)Rb, —(CH2)p—C(S)NHRb, —(CH2)p—SO2Rb, —(CH2)p—SO2NHRb;
• p is 0, 1, 2 or 3;
• Rc and Rc′ are each independently selected from the group consisting of H, hydroxyl, amino group, NRaRa′, halogen, cyano, nitro, carboxyl, formyl, amide group, ester group, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 heteroalkyl, C1-6 alkoxy, C1-6 alkoxyalkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, 5-10 membered heteroaryl, C3-10 cycloalkyl, 3-10 membered heterocycloalkyl, 3-7 membered heterocycloalkenyl, C1-6 alkyl C6-10 aryl, 5-10 membered heteroaryl C1-6 alkyl or C1-6 alkyl 5-10 membered heteroaryl;
• preferably selected from the group consisting of H, hydroxyl, amino group, NRaRa′, halogen, carboxyl, formyl, amide group, ester group, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 heteroalkyl, C1-6 alkoxyl, C3-10 cycloalkyl, 3-10 membered heterocycloalkyl, substituted or unsubstituted phenyl or pyridyl;
• R3, R4, and R5 are each independently selected from the group consisting of H, hydroxyl, amino group, halogen, cyano, nitro, carboxyl, formyl, amide group, —NH—CORb, ester group, C1-6 alkyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 heteroalkyl, C1-6 alkoxy, C1-6 alkoxyalkyl, C2-6 alkenyl, C2-6 alkynyl, unsubstituted or substituted —CONH—(C6-10 aryl), unsubstituted or substituted —CH═CH—(C6-10 aryl), unsubstituted or substituted C6-10 aryl, unsubstituted or substituted 5-10 membered heteroaryl, unsubstituted or substituted C3-10 cycloalkyl, unsubstituted or substituted 3-10 membered heterocycloalkyl, unsubstituted or substituted 3-7 membered heterocycloalkenyl, unsubstituted or substituted C6-10 aryl C1-6 alkyl, unsubstituted or substituted C1-6 alkyl C6-10 aryl, unsubstituted or substituted 5-10 membered heteroaryl C1-6 alkyl, and unsubstituted or substituted C1-6 alkyl 5-10 membered heteroaryl;
• or two adjacent groups in R3, R4 and R5 may be bonded to form an unsubstituted or substituted C6-10 aryl group, an unsubstituted or substituted 5-10 membered heteroaryl group, an unsubstituted or substituted C3-10 cycloalkyl group, or an unsubstituted or substituted 3-10 membered heterocycloalkyl group;
• wherein each Rb is independently C1-6 alkyl, C2-6 alkenyl, NHRa, NRaRa′, unsubstituted or substituted phenyl or 3-7 membered heterocyclic group;
• Ra and Ra′ are each independently H or C1-6 alkyl;
• unsubstituted or substituted means that the group is unsubstituted or substituted by one or more substituents selected from the group consisting of hydroxyl, amino group, cyano, nitro, carboxyl, halogen, C1-6 alkyl, C1-6 haloalkyl or C1-6 hydroxyalkyl, or two adjacent substituents may be bonded to form a C6-10 aryl group, a C5-10 heteroaryl group, a C3-10 cycloalkyl group or a C3-10 heterocycloalkyl group;
• and meets the following conditions:
• (1) when W, Z or T is substituted by one group of R3, R4 and R5, the W, Z or T is N or CH;
• (2) when W, Z or T is substituted by one group of R3, R4 and R5 and this group is bonded to another adjacent group of R3, R4 and R5 to form an unsubstituted or substituted C6-10 aryl or unsubstituted or substituted 5-10 membered heteroaryl, the W, Z or T is C;
• (3) when W, Z or T is substituted by two of R3, R4 and R5, the W, Z or T is C.