Conformationally strained trans-cycloalkenes for radiolabeling
AssigneesUniversity of Delaware, The University of North Carolina at Chapel Hill, United Kingdom Research and Innovation
InventorsJoseph FOX, Zibo LI, Yu LIU, Michael Thompson TAYLOR, Dennis SVATUNEK, Katarina ROHLFING, Mengzhe WANG, Zhanhong WU, Raghu VANNAM, Jason W. CHIN, Stephen WALLACE
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Abstract
Conformationally strained irans-cycloalkenes and derivatives thereof suitable for radiolabeling in a subject in need thereof.
Claims17
-42. (canceled)
A compound having orae of the following structures:
- wherein M is a radioactive or a non-radioactive isotope of a metal.
A compound having one sf the following structures:
- wherein M is a radioactive or a non-radioactive isotope of a metal.
A compound having one of the following structures:
- wherein M is a radioactive or a non-radioactive isotope of a metal, and
- wherein R is chosen from hydrogen and methyl.
A compound having one of the following structures:
- wherein M is a radioactive or a non-radioactive isotope of a metal.
A compound having one of the following structures:
- wherein M is a radioactive or a non-radioactive isotope of a metal.
A compound having one of the following structures:
- wherein M is a radioactive or a non-radioactive isotope of a metal.
A compound having one of the following structures:
- wherein the halogen is an isotope of chlorine, bromine, iodine or astatine, and
- wherein R is chosen from hydrogen and methyl.
A method of PET imaging, comprising injecting into a subject in need of said imaging an 18F compound having one of the following structures:
- wherein the halogen is an isotope of chlorine, bromine, iodine or astatine, and
- wherein R is chosen from hydrogen and methyl.
Dependencies are inferred from the claim text.