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US 2020/0170946 A1Published application
Nanoparticle-lipid composite carriers and uses thereof
AssigneeNorthwestern University
InventorsVinayak P. Dravid, Vikas Nandwana
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Abstract
Provided herein are nanoparticle-lipid composite carriers as theranostic agents, particularly for diagnosis and/or treatment of cancers and related diseases and conditions. In particular embodiments, the carrier composites comprise a lipid core and an outer shell of functionalized nanoparticles (fNPs).
Claims23
A nanoparticle-lipid composite carrier, comprising:
- (a) a hydrophobic core comprising tails of a plurality of lipid molecules;
- and
- (b) a shell comprising surface-functionalized nanostructures assembled on heads of the plurality of lipid molecules.
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A method of synthesizing a nanoparticle-lipid composite carrier, comprising:
- contacting lipid molecules with surface-functionalized nanostructures under conditions such that a nanoparticle-lipid composite carrier comprising a hydrophobic core comprising tails of a plurality of the lipid molecules and a shell comprising the surface-functionalized nanostructures assembled on heads of the plurality of the lipid molecules is self-assembled.
Dependencies are inferred from the claim text.