Water-soluble gold (iii) complexes, methods of producing water-soluble gold (iii) complexes and their use
OwnerStanislaw SZCZEPANIAK, Elwira SZCZEPANIAK +3inventors
InventorsStanislaw SZCZEPANIAK, Elwira SZCZEPANIAK, Remigiusz SZCZEPANIAK, Dominika SZCZEPANIAK, Monika SZCZEPANIAK
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Abstract
The present invention relates to a process for the preparation of a composition comprising a gold (111) chlorite-cyanide coordination compound, a composition comprising the gold (111) compound obtainable by this process, as well as the afore-mentioned composition for use in therapy, more particularly for use in the treatment of cancer.
Claims15
A process for the preparation of a composition comprising a gold(+III) compound comprising the steps of:
- a) providing a mixture A comprising a tetrachloroaurate salt,
- b) mixing the composition of step a) with a mixture B comprising a chlorite salt;
- c) mixing the composition obtained in step b) with a mixture C comprising an alkaline earth cyanide to obtain a composition comprising a gold (+III) compound.
The process according to any one of the preceding claims, wherein the chlorite salt of mixture B is an alkali chlorite, and preferably sodium chlorite,
- and/or wherein the amount of chlorite salt used in mixture B and the amount of the gold(+III) compound used in mixture A have a molar ratio of from 10:1 to 1:2, preferably from 5:1 to 1:1, and most preferably from 3:1 to 1.5:1.
The process according to any one of the preceding claims, wherein mixture B further comprises water and/or the chlorite salt is present in mixture B in a weight amount of 0.1 wt. % to 10 wt. %, preferably from 1 wt. % to 5 wt. %, and most preferably from 2 wt. % to 3 wt. %, based on the total weight of mixture B.
The process according to any one of the preceding claims, wherein the process further comprises a step b1) of adjusting the pH of the composition obtained in step b) to an pH value of from 5 to 9, preferably from 6 to 8, and more preferably from 7 to 8, preferably by using a carbonate base, and more preferably sodium hydrogen carbonate.
The process according to any one of the preceding claims, wherein the alkaline earth cyanide of mixture C is selected from the group of magnesium cyanide, calcium cyanide, or a mixture thereof, preferably magnesium cyanide, and/or wherein mixture C further comprises water and/or an organic solvent.
The process according to any one of the preceding claims, wherein the process further comprises a step d) of mixing the composition obtained in step c) with an acid, and/or subjecting the composition obtained in step c) to reduced pressure.
The process according to any one of the preceding claims, wherein the process further comprises a step e) of adjusting the pH of the composition obtained in step c) or d) to a value of from 7 to 8.
Dependencies are inferred from the claim text.