Processes of making l-ornithine phenylacetate
AssigneeOcera Therapeutics, Inc.
InventorsLudwig PILSL, Georg WINKLER, Frank DEMARTIN, Vassil ELITZIN
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Abstract
Embodiments of the present disclosure are related to improved processes for making L-ornithine phenylacetate without using any silver salts or forming any L-ornithine intermediate salts, such as a benzoate salt. The present processes may be used in the commercial scale manufacturing of L-ornithine phenylacetate with high yields and low impurities.
Claims26
A process of making L-ornithine phenylacetate, comprising:
- intermixing L-ornithine hydrochloride and potassium hydroxide in a first solvent to form a first reaction mixture;
- adding a second solvent to said first reaction mixture;
- isolating potassium chloride from said first reaction mixture;
- intermixing phenylacetic acid with said first reaction mixture to form a second reaction mixture;
- and
- isolating a composition comprising L-ornithine phenylacetate from said second reaction mixture.
A composition comprising L-ornithine phenylacetate, having a chloride content of less than about 1.5% by weight, wherein said composition is free of silver ion, benzoic acid or salts thereof.
Dependencies are inferred from the claim text.