Biodegradable hydrogel and methods for use thereof
AssigneesInternational Business Machines Corporation, Institute of Bioengineering and Nanotechnology
InventorsMareva B. Fevre, James L. Hedrick, Ashlynn Lee, Nathaniel H. Park, Rudy J. Wojtecki, Yi Yan Yang, Zhi Xiang Voo
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Abstract
The subject matter of this invention relates to hydrogel compositions and, more particularly, to hydrogel compositions comprising block copolymers (BCPs) capable of self-assembly into nanoparticles for the delivery and controlled release of therapeutic cargos.
Claims25
A hydrogel composition comprising:
- a first ABA triblock copolymer having negatively charged A blocks;
- and
- a second ABA triblock copolymer having positively charged A blocks.
A hydrogel composition comprising:
- an AB diblock copolymer having a negatively charged A block;
- and
- an ABA triblock copolymer having positively charged A blocks.
A micellar particle comprising:
- a hydrogel composition comprising:
- a first ABA triblock copolymer having negatively charged A blocks;
- and
- a second ABA triblock copolymer having positively charged A blocks;
- and
- at least one agent for delivery within the hydrogel composition.
A micellar particle comprising:
- a hydrogel composition comprising:
- an AB diblock copolymer having a negatively charged A block;
- and
- an ABA triblock copolymer having positively charged A blocks;
- and
- at least one agent for delivery within the hydrogel composition.
A method of treating, in an individual in need of such treatment, a disease or disorder amenable to treatment with a therapeutic agent, the method comprising:
- administering to the individual a hydrogel composition selected from a group consisting of:
- (a) a hydrogel composition comprising:
- a first ABA triblock copolymer having negatively charged A blocks;
- a second ABA triblock copolymer having positively charged A blocks;
- and
- at least one agent for delivery within the hydrogel composition;
- and
- (b) a hydrogel composition comprising:
- an AB diblock copolymer having a negatively charged A block;
- and
- a third ABA triblock copolymer having positively charged A block;
- and
- at least one agent for delivery within the hydrogel composition.
Dependencies are inferred from the claim text.