Infectious disease vaccine using non-infectious paramyxovirus particle
AssigneesJapan AS Represented By Director-General of National Institute of Infectious Diseases, ID Pharma Co., Ltd.
InventorsTetsuro MATANO, Makoto INOUE, Hiroto HARA, Tsugumine SHU
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Abstract
In this invention, a non-infectious particle has been produced, comprising a pathogen antigen protein caused to be expressed on the surface of a virus particle having at least one species of paramyxovirus envelope protein missing from the particle. This particle has been found to hold within the particle a large amount of antigen protein compared to an infectious particle, and to be capable of eliciting a host immune response with extremely high efficiency. The non-infectious particle according to the present invention is useful as a vaccine against a pathogenic virus, or the like.
Claims17
A paramyxovirus non-infectious particle, which expresses an antigen protein of a heterologous pathogen on the surface of the virus particle.
A paramyxovirus vector in which at least one envelope protein gene has been deleted from the genome and which carries an antigen protein gene of a heterologous pathogen, wherein the vector expresses the antigen protein gene of the heterologous pathogen on the surface of the virus particle.
Dependencies are inferred from the claim text.