Preparation of biologically active complexes
AssigneeHamlet Pharma AB
InventorsAftab NADEEM, Catharina SVANBORG, Chin Shing HO
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Abstract
The invention provides a method for preparing a biologically active complex, said method comprising dissolving a mixture of a polypeptide element, such as alphalactalbumin or fragments thereof, in powder form and oleic acid or a pharmaceutically acceptable salt thereof also in solid form, in an aqueous solvent comprising a mixture of at least two and preferably three salts, wherein the method is carried out at moderate temperatures. The preparation does not require extensive heating and so is simple and efficient to carry out.
Claims26
A method for preparing a biologically active complex, said method comprising dissolving a mixture of a polypeptide element in powder form and oleic acid or a pharmaceutically acceptable salt thereof also in solid form, in an aqueous solvent comprising at least two salts, the first of which is sodium or potassium chloride and the second of which is disodium phosphate or mono-potassium phosphate, wherein the process is carried out at moderate temperature of up to 50° C.
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A biologically active complex comprising a peptide of SEQ ID NO 6 and oleic acid or a salt thereof.
A peptide of SEQ ID NO 6.
Dependencies are inferred from the claim text.