Method of inducing cardiomyocytes proliferation and treating heart diseases
AssigneeYeda Research and Development Co. Ltd.
InventorsEldad TZAHOR, Elad BASSAT
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Abstract
An Agrin peptide which induces proliferation of cardiomyocytes for treating a heart disease is provided.
Claims21
A method of inducing proliferation of cardiomyocytes, the method comprising contacting the cardiomyocytes with an effective amount of an Agrin peptide which induces proliferation of the cardiomyocytes, wherein said agrin peptide is 80-110 kDa and is not a part of a fusion polypeptide.
A method of treating a heart disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an agrin peptide which induces proliferation of cardiomyocytes, wherein said agrin peptide induces proliferation of the cardiomyocytes and is not a part of a fusion polypeptide and is 80-110 kDa, thereby treating the heart disease.
A method of treating a heart disease selected from the group consisting of coronary arteriosclerosis, acute myocardial infarction (AMI), myocardial infarction (MI), old MI, angina pectoris (AP), and ischemic cardiomyopathy in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an agrin peptide which induces proliferation of cardiomyocytes, wherein said agrin peptide induces proliferation of the cardiomyocytes and is not a part of a fusion polypeptide, thereby treating the heart disease.
Dependencies are inferred from the claim text.