Radioactive probe for detecting hydrogen sulfide
AssigneeKyungpook National University Industry-Academic Cooperation Foundation
InventorsJeong Soo YOO, Swarbhanu SARKAR, Yeong Su HA, Woong Hee LEE
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AssigneeKyungpook National University Industry-Academic Cooperation Foundation
InventorsJeong Soo YOO, Swarbhanu SARKAR, Yeong Su HA, Woong Hee LEE
Estimating the term…
Provided is a probe for detecting in vivo hydrogen sulfide, specifically, a probe for detecting hydrogen sulfide including a complex compound into which a radioactive isotope Cu is introduced. According to specific embodiments of the present disclosure, as a result of real-time observing animal models, in which hydrogen sulfide involved in various diseases is generated in a large quantity, through optical and nuclear medicine imaging, the probe for detecting hydrogen sulfide according to the present disclosure may selectively bind with hydrogen sulfide to provide images of a site where hydrogen sulfide has abnormally increased in a cell or a tissue, thereby detecting a disease in an unexpected site without affecting the anatomical properties of the body. Accordingly, the probe may be effectively used as a means for diagnosing diseases, such as a composition for imaging, an imaging method, etc.
A method of measuring, detecting or imaging hydrogen sulfide in a cell or a tissue comprising administering the probe for detecting hydrogen sulfide comprising the radioactive isotope Cu-introduced complex compound which is represented by the following Chemical Formula 1;
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