Methods and compositions for the detection of cancer
AssigneeCase Western Reserve University
InventorSusann Brady-Kalnay
Life of this patent
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Abstract
A molecular probe for use in detection of cancer cells expressing an Ig superfamily cell adhesion molecule that binds in a homophilic fashion in a subject includes a targeting agent that specifically binds to and/or complexes with a proteolytically cleaved extracellular fragment of the Ig superfamily cell adhesion molecule.
Claims21
1-41. (canceled)
A molecular probe comprising a targeting agent and a detectable moiety, the targeting agent comprising a polypeptide that homophilically binds to a proteolytically cleaved extracellular fragment of an immunoglobulin (Ig) superfamily cell adhesion molecule that is expressed by a cancer cell.
A method of detecting cancer cells and/or cancer cell metastasis, migration, dispersal, and/or invasion of cancer cells expressing an Ig superfamily cell adhesion molecule, the method comprising:
- administering to cancer cells a molecular probe that includes a targeting agent and a detectable moiety, the targeting agent comprising a polypeptide that homophilically binds to a proteolytically cleaved extracellular fragment of the immunoglobulin (Ig) superfamily cell adhesion molecule that is expressed by the cancer cells;
- and
- detecting the molecular probe bound to and/or complexed with the proteolytically cleaved extracellular fragment of the cell adhesion molecule.
Dependencies are inferred from the claim text.