Fibroblast Growth Factor Receptor 2-Specific Peptide Reagents and Methods
AssigneeThe Regents of the University of Michigan Office of Technology Transfer
InventorsThomas D. Wang, Juan Zhou
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Abstract
The present disclosure relates to Fibroblast Growth Factor Receptor 2-specific peptide reagents, methods for detecting epithelial-derived cancer cells such as esophageal, colorectal, gastric, pancreatic or breast carcinoma cells using the peptide reagents, and methods for targeting such cells using the peptide reagents.
Claims28
A reagent comprising a fibroblast growth factor receptor 2-specific peptide SRRPASFRTARE (SEQ ID NO:
- 1), or a multimer form of the peptide,
- wherein the peptide specifically binds to fibroblast growth factor receptor 2 and
- wherein at least one detectable label, at least one therapeutic moiety, or both, are attached to the peptide or a multimer form of the peptide.
The reagent of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 or 11 comprising at least one therapeutic moiety attached to the peptide.
A peptide consisting of the amino acid sequence SRRPASFRTARE (SEQ ID NO:
- 1).
Dependencies are inferred from the claim text.