Compositions and methods for targeted delivery of therapeutic and/or diagnostic agents
AssigneeThe Penn State Research Foundation
InventorsJian Yang, Cheng Dong, Zhiwei Xie
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Abstract
In one aspect, methods of targeted nanoparticles and cell delivery are described herein, In some embodiments methods described herein comprise coupling nanoparticles and cells to a carrier cell to form a nanoparticle cell conjugate or cell-cell conjugate disposing the nanoparticle cell or cell-cell conjugate in a biological environment and delivering the nanoparticles and cells to target cells or tissues located within the biological environment The nanoparticles comprise a biodegradable photoluminescent polymer, and the nanoparticle cell conjugate is formed using one or more click chemistry reaction products
Claims21
1-76. (canceled)
A composition comprising:
- a stem cell;
- a carrier cell;
- and
- a linker attaching the stem cell to the carrier cell,
- wherein the stem cell is coupled to the linker by a first click-chemistry reaction product, and the linker is coupled to the carrier cell to form a stem cell-peptide-carrier cell conjugate.
A stem cell-linker-carrier cell conjugate comprising:
- a linker;
- a stem cell connected to a linker through, a first click-chemistry reaction product;
- and
- a carrier cell connected to the linker through a second click-chemistry reaction product.
A method of targeted stem cell delivery comprising:
- providing the composition of claim 1;
- disposing the composition in a biological environment;
- and
- coupling the composition to a target tissue by an interaction between the carrier cell and the target tissue.
Dependencies are inferred from the claim text.