Dll3 modulators and methods of use
AssigneeAbbvie Stemcentrx LLC
InventorsRobert A. Stull, Laura Saunders, Scott J. Dylla, Orit Foord, David Liu, Michael Torgov, Hui Shao
Life of this patent
Estimating the term…
Abstract
Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat proliferative disorders are provided.
Claims9
-20. (canceled)
A polypeptide comprising a first set of three non-contiguous sequences of amino acids, wherein at least 90% of the amino acids of the first set of three non-contiguous sequences are identical to:
- (SEQ ID NO:
- 427)
- (1) TASSSVSSSY;
- (SEQ ID NO:
- 428)
- (2) STSNLAS;
- and
- (SEQ ID NO:
- 429)
- (3) HQX1X2RSPX3TFGX4GTKLX5X6X7,
- wherein X1 is F or Y;
- X2 is H or N;
- X3 is L or F;
- X4 is A or S;
- X5 is E or K;
- X6 is L on;
- and X7
- is K or R.
A humanized light chain comprising a light chain variable region having three complementarity determining regions (CDRs), wherein the three CDRs comprise a non-contiguous amino acid sequence having at least 85% identity to a set of CDRs from a donor sequence comprising:
- (SEQ ID NO:
- 427)
- (1) TASSSVSSSYL;
- (SEQ ID NO:
- 428)
- (2) STSNLAS;
- and
- (SEQ ID NO:
- 430)
- (3) HQX1X2RSPX3T,
- wherein X1 is F or Y;
- X2 is H or N;
- and X3
- is L or F.
A nucleic acid comprising a first set of three non-contiguous nucleotide sequences, wherein the first set of nucleotide sequences has at least 95% identity to a polynucleotide encoding a polypeptide comprising:
- (SEQ ID NO:
- 427)
- (1) TASSSVSSSY;
- (SEQ ID NO:
- 428)
- (2) STSNLAS;
- and
- (SEQ ID NO:
- 429)
- (3) HQX1X2RSPX3TFGX4GTKLX5X6X7,
- wherein X1 is F or Y;
- X2 is H or N;
- X3 is L or F;
- X4 is A or S;
- X5 is E or K;
- X6 is L or I;
- and X7 is
- K or R.
Dependencies are inferred from the claim text.