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US 2020/0138964 A1Published application
Tertiary amine compound or imine compound-polymer conjugate and production method therefor
AssigneeSeikagaku Corporation
InventorsNobuo Kobayashi, Yosuke Yasuda, Kenichi Namatsu
Life of this patent
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Abstract
Provided is a compound obtained by conjugating a tertiary amine compound or imine compound, which is useful as a drug, with a polymer, in which a structure D+ having a quaternary ammonium salt or iminium salt formed from a tertiary amine compound or imine compound D and a polymer residue Poly having a carboxy group are bonded to each other via a structure —C(R1)(R2)OC(O)ANHC(═O)—.
Claims13
A compound represented by Formula (I) or a pharmaceutically acceptable salt thereof;
- in Formula (I), D+ is a structure forming a quaternary ammonium salt or an iminium salt from D, a tertiary amine compound or an imine compound;
- a nitrogen atom forming the quaternary ammonium salt or the iminium salt and a carbon atom to which R1 and R2 bond are bonded to each other, R1 and R2 are each independently a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted cycloalkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted cycloalkenyl group, a substituted or unsubstituted alkynyl group, a substituted or unsubstituted aromatic group, or a substituted or unsubstituted heterocyclic group;
- A is a bivalent hydrocarbon group in which a carbon other than carbons at both ends may be substituted with a hetero atom selected from the group consisting of an oxygen atom, a nitrogen atom and a sulfur atom;
- any two or three groups of R1, R2, and A may combine together to form a ring;
- and Poly is a polymer residue having a carboxy group.
2 more elements
Dependencies are inferred from the claim text.