Chlamydia nanoemulsion vaccine
AssigneeNanoBio Corporation
InventorsAli FATTOM, Vira BITKO
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Abstract
The present application relates to the field of human immunology, in particular, a chlamydia vaccine. The subunit vaccine composition may comprise isolated antigens from chlamydia bacteria, fusion proteins or fragments thereof, live or attenuated bacteria, or other bacterial components mixed in varied combination with a nanoemulsion, which provides a potent immune enhancer.
Claims18
A vaccine composition comprising:
- (a) an immune enhancing nanoemulsion, wherein the nanoemulsion comprises an oil-in-water nanoemulsion or a dilution thereof;
- and
- (b) at least one chlamydia bacteria antigen, wherein the chlamydia bacteria antigen is whole chlamydia, an isolated chlamydia antigen, a recombinant chlamydia antigen, or a combination thereof, and wherein the chlamydia bacteria antigen is present within the nanoemulsion.
(canceled)
A method for preparing a nanoemulsion chlamydia bacteria vaccine useful for the treatment or prevention of an chlamydia infection in a subject comprising:
- (a) synthesizing in a prokaryotic host one or more full length or immunogenic fragment chlamydia bacteria antigens utilizing recombinant DNA genetics vectors and constructs, wherein the chlamydia bacteria antigen is selected from the group consisting of major outer-membrane protein (MOMP), chlamydial outer-membrane complex (COMC), polymorphic outer-membrane proteins (POMPs or Pmps), the 60 and 75 kDa heat-shock proteins, the type-III secretory system structural proteins, exoglycolipid, Inc proteins, Cap1, CT111, CT242, CT687, CT823, and CT144;
- (b) isolating the one or more antigens or immunogenic fragments thereof from the prokaryotic host;
- and
- (c) formulating the one or more antigens with an oil-in-water nanoemulsion.
A subunit vaccine composition comprising an immune enhancing nanoemulsion combined with one or more chlamydia bacteria antigens, wherein the nanoemulsion further comprises an oil-in-water nanoemulsion or a dilution thereof and isolated viral antigens preferentially comprised within the nanoemulsion.
A method of treating a subject in need comprising administering to the subject a nanoemulsion chlamydia bacteria vaccine composition, wherein following administration the vaccine induces an immune response against infection caused by chlamydia bacteria in the subject, and wherein the vaccine composition comprises:
- (a) an immune enhancing nanoemulsion, wherein the nanoemulsion comprises an oil-in-water nanoemulsion or a dilution thereof;
- and
- (b) at least one chlamydia bacteria antigen, wherein the chlamydia bacteria antigen is whole chlamydia, an isolated chlamydia antigen, a recombinant chlamydia antigen, or a combination thereof, and wherein the chlamydia bacteria antigen is present within the nanoemulsion.
Dependencies are inferred from the claim text.