Methods and compositions for natural killer cells
AssigneeUniversity of Central Florida Research Foundation, Inc.
InventorsAlicja Copik, Vijay Reddy, Jeremiah Oyer
Life of this patent
Estimating the term…
Abstract
The application provides new compositions and methods for stimulating the production of natural killer (NK) cells in a subject. NK cells can be selectively expanded with a combination of stimulating ligands. Methods and compositions for the administration of stimulatory ligands modified to self-insert into tumor cells, thereby stimulating an increase in the number of NK cells in proximity to a tumor, are also described.
Claims19
1-38. (canceled)
A method of treating cancer comprising administering to a subject an effective amount of a composition comprising a membrane self-inserting peptide conjugated to an NK cell effector agent.
40-41. (canceled)
45-58. (canceled)
A method of expanding NK cells comprising administering to a cell population an effective amount of a composition comprising a membrane self-inserting peptide conjugated to an NK cell effector agent, wherein the cell population comprises NK cells.
60-61. (canceled)
A method of modulating the immune system comprising administering to a subject one or more of a composition comprising a membrane self-inserting peptide conjugated to an NK cell effector agent.
71-74. (canceled)
Dependencies are inferred from the claim text.