New heteroaryl amide derivatives as selective inhibitors of histone deacetylases 1 and/or 2 (hdac1-2)

A compound of formula (I):

• wherein:
• X1 and X2 represent, independently, CH or N;
• R1 represents:
• a) phenyl group optionally substituted by one or more substituents selected from the group consisting of halogen atom, linear or branched C1-C4 haloalkyl group, and linear or branched alkoxy,
• b) five or a six-membered heteroaryl ring optionally substituted by one or more substituents selected from the group consisting of halogen atom, linear or branched C1-C4 alkoxy, cyano group, linear or branched C1-C4 haloalkyl, linear or branched C1-C3 alkyl, C3-C6 cycloalkyl, C3-C6 cycloalkoxy and C5-C6 heterocyclic ring optionally substituted by one or more halogen atoms;
• R2 represents:
• a) —N(R3) (R4) group, wherein:
• 1—R3 and R4 form together with the nitrogen atom to which they are bound a five or six-membered saturated heterocycle comprising optionally an additional heteroatom as part of the cycle selected from N and O, which is optionally substituted by a C1-C3 alkyl group or an —N(R5) (R6) group, wherein R5 and R6 form together with the nitrogen atom to which they are bound a five or six-membered saturated heterocycle comprising optionally an additional heteroatom as part of the cycle selected from N and O, which is optionally substituted by a C1-C3 alkyl group, or
• 2—R3 and R4 represent independently a group selected from hydrogen atom, C3-C6 cycloalkyl group and linear or branched C1-C3 alkyl, which is optionally substituted by a five or six-membered heterocycle comprising one or two heteroatoms as part of the cycle selected from N and O, which is optionally substituted by linear or branched C1-C3 alkyl group,
• b) phenyl ring optionally substituted by one or more substituent selected from halogen atoms and cyano group,
• c) C3-C6 cycloalkyl optionally substituted by one or more substituent selected from linear or branched C1-C3 alkyl and hydroxy group,
• d) C5-C6 heteroaryl optionally substituted by a group selected from halogen atom, linear or branched C1-C3 alkyl and linear or branched C1-C4 alkoxy and —N(R5) (R6) group, wherein R5 and R6 form together with the nitrogen atom to which they are bound a five or six-membered saturated cycle comprising optionally an additional heteroatom selected from N and O as part of the cycle, which is optionally substituted by a C1-C3 alkyl group, or
• e) hydrogen atom,
• or pharmaceutically acceptable salts thereof.