Methods of treatment for cystic fibrosis
AssigneeVertex Pharmaceuticals Incorporated
InventorsWeichao George Chen, Eric L. Haseltine, Samuel Moskowitz, Sarah Robertson, David Waltz
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Abstract
Compound I of the formula (I) and/or pharmaceutically acceptable salt(s) of Compound I comprised in a pharmaceutical composition and methods of using the same to treat cystic fibrosis.
Claims97
A method of treating cystic fibrosis comprising administering to a patient in need thereof:
- (a) 10 mg to 900 mg of at least one compound chosen from Compound I:
- and pharmaceutically acceptable salts thereof daily;
- and
- (b) at least one compound chosen from (i) Compound II:
- (ii) Compound III or Compound III-d:
- and
- (iii) Compound IV:
- and pharmaceutically acceptable salts of any of the foregoing.
A method of treating cystic fibrosis comprising administering to a patient in need thereof:
- 200 mg of at least one compound chosen from Compound I and pharmaceutically acceptable salts thereof once daily:
- and
- 100 mg of at least one compound chosen from Compound II and pharmaceutically acceptable salts thereof once daily:
- and
- 150 mg per dose of at least one compound chosen from Compound III and pharmaceutically acceptable salts thereof twice daily:
A method of treating cystic fibrosis comprising administering to a patient in need thereof:
- 100 mg per dose of at least one compound chosen from Compound I and pharmaceutically acceptable salts thereof twice daily:
- and
- 50 mg per dose of at least one compound chosen from Compound II and pharmaceutically acceptable salts thereof twice daily:
- and
- 150 mg per dose of at least one compound chosen from Compound III and pharmaceutically acceptable salts thereof twice daily:
A method of treating cystic fibrosis comprising administering to a patient in need thereof:
- 200 mg of at least one compound chosen from Compound I and pharmaceutically acceptable salts thereof once daily:
- and
- (B) 100 mg of at least one compound chosen from Compound II and pharmaceutically acceptable salts thereof once daily:
- and
- (C) 150 mg of at least one compound chosen from Compound III-d and pharmaceutically acceptable salts thereof once daily:
A pharmaceutical composition comprising 10 mg to 900 mg of at least one compound chosen from Compound I and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.