Spirocyclic Indolines as IL-17 Modulators

A compound of formula (I), or a pharmaceutically acceptable salt thereof:

• wherein
• ring A represents C3-9 cycloalkyl, C3-7 heterocycloalkyl or C4-9 heterobicycloalkyl, any of which groups may be optionally substituted by one or more substituents;
• B represents C—R2 or N;
• D represents C—R3 or N;
• E represents C—R4 or N;
• R0 represents hydrogen or C1-6 alkyl;
• R1 represents —CORa or —SO2Rb;
• or R1 represents C1-6 alkyl, C3-9 cycloalkyl, C3-9 cycloalkyl(C1-6)alkyl, C5-9 spirocycloalkyl(C1-6)alkyl, aryl, aryl(C1-6)alkyl, C3-7 hetero-cycloalkyl, C3-7 heterocycloalkyl(C1-6)alkyl, heteroaryl or heteroaryl(C1-6)alkyl, any of which groups may be optionally substituted by one or more substituents;
• R2 represents hydrogen, halogen, cyano, C1-6 alkyl, fluoromethyl, difluoromethyl, trifluoromethyl, hydroxy, C1-6 alkoxy, difluoromethoxy, trifluoromethoxy, C1-6 alkyl-sulphinyl or C1-6 alkylsulphonyl;
• R3 represents hydrogen, halogen, cyano, 01-6 alkyl, fluoromethyl, difluoromethyl, trifluoromethyl, hydroxy, C1-6 alkoxy, difluoromethoxy, trifluoromethoxy, C1-6 alkyl-sulphinyl or C1-6 alkylsulphonyl;
• R4 represents hydrogen, halogen, cyano, C1-6 alkyl, fluoromethyl, difluoromethyl, trifluoromethyl, hydroxy, C1-6 alkoxy, difluoromethoxy, trifluoromethoxy, C1-6 alkyl-sulphinyl or C1-6 alkylsulphonyl;
• Ra represents hydrogen;
• or Ra represents C1-6 alkyl, C2-7 alkenyl, C3-9 cycloalkyl, C3-9 cycloalkyl(C1-6)alkyl, C3-9 cycloalkylidenyl(C1-6)alkyl, C4-9 bicycloalkyl(C1-6)alkyl, C4-9 bicycloalkylidenyl(C1-6)alkyl, C5-9 spirocycloalkyl(C1-6)alkyl, C9-11 tricycloalkyl-(C1-6)alkyl, aryl, aryl(C1-6)alkyl, C3-7 heterocycloalkyl, C3-7 heterocycloalkyl(C1-6)alkyl, C3-7 heterocycloalkylidenyl(C1-6)alkyl, heteroaryl or heteroaryl(C1-6)alkyl, any of which groups may be optionally substituted by one or more substituents;
• and
• Rb represents C1-6 alkyl, C2-7 alkenyl, C3-9 cycloalkyl, C3-9 cycloalkyl(C1-6)alkyl, C3-9 cycloalkylidenyl(C1-6)alkyl, C4-9 bicycloalkyl(C1-6)alkyl, C4-9 bicycloalkylidenyl-(C1-6)alkyl, C5-9 spirocycloalkyl(C1-6)alkyl, C9-11 tricycloalkyl(C1-6)alkyl, aryl, aryl(C1-6)-alkyl, C3-7 heterocycloalkyl, C3-7 heterocycloalkyl(C1-6)alkyl, C3-7 heterocycloalkylidenyl-(C1-6)alkyl, heteroaryl or heteroaryl(C1-6)alkyl, any of which groups may be optionally substituted by one or more substituents.