Controlling biofilms with cyclopropanated fatty acids
AssigneeThe University of Memphis Research Foundation
InventorsJessica Amber Jennings, Daniel Lee Baker, Rukhsana Awais, Zoe Harrison, Babatunde Raji
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Abstract
Compositions and methods for using cyclopropanated structural analogs of fatty acid biofilm dispersal agents are characterized by superior biofilm dispersion. When used in combination with antimicrobials, these analogs decrease the minimum inhibitory concentration of antimicrobial agents required for eradication of the biofilm and/or treatment of infection. Methods for using these analogs include direct application to a surface, blending with lipid based carriers, or covalent anchoring the molecule to a surface.
Claims30
A biofilm removing and/or inhibiting composition comprising one or more compounds derived from a mono-unsaturated fatty acid, wherein said compound is cyclopropanated at the double bond of said fatty acid, and wherein said fatty acid is effective to remove or disrupt a bacterial biofilm or inhibit normal biofilm formation.
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A method of inhibiting biofilm formation on a surface comprising inserting one or more compounds derived from a mono-unsaturated fatty acid onto said surface, wherein said compound is cyclopropanated at the double bond of said fatty acid, and wherein said fatty acid is effective to remove or disrupt a bacterial biofilm or inhibit normal biofilm formation.
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A biomedical device comprising one or more compounds derived from a mono-unsubstituted fatty acid, wherein said compound is cyclopropanated at the double bond of said fatty acid, and wherein said fatty acid is effective to remove or disrupt a bacterial biofilm or inhibit normal biofilm formation.
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Dependencies are inferred from the claim text.