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AssigneesEmory University, Bar-Ilan University, Children's Healthcare of Atlanta, Inc.
InventorsNael McCarty, Guiying Cui, Hanoch Senderowitz, Netaly Khazanov
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This disclosure relates to methods of treating or preventing cystic fibrosis transmembrane conductance regulator (CFTR) mediated diseases such as cystic fibrosis, chronic obstructive pulmonary disease, chronic pancreatitis, chronic bronchitis, asthma, mucus formation, comprising administering an effective amount of a 2-amino-N′-benzylidene-acetohydrazide compound or derivative thereof to a subject in need thereof. In certain embodiments, the 2-amino-N′-benzylidene-acetohydrazide compound is ((E)-N′-(3,5-dibromo-2,4-dihydroxybenzylidene)-2-(m-tolylamino)acetohydrazide; or (E)-N′-(3,5-dibromo-2,4-dihydroxybenzylidene)-2-(p-tolylamino)acetohydrazide.
A method of treating chronic obstructive pulmonary disease comprising administering an effective amount of ((E)-N′-(3,5-dibromo-2,4-dihydroxybenzylidene)-2-(m-tolylamino)acetohydrazide or salt thereof to a subject wherein the subject is diagnosed with chronic obstructive pulmonary disease.
A method of treating chronic obstructive pulmonary disease comprising administering an effective amount of ((E)-N′-(3,5-dibromo-2,4-dihydroxybenzylidene)-2-(p-tolylamino)acetohydrazide or salt thereof to a subject wherein the subject is diagnosed with chronic obstructive pulmonary disease.
Dependencies are inferred from the claim text.