Methods for inhibiting conversion of choline to trimethylamine (tma)
AssigneesThe Procter & Gamble Company, The Cleveland Clinic Foundation
InventorsStanley Leon HAZEN, Jose Carlos GARCIA-GARCIA, Jodie Michelle REED, Lori Ann REINSALU, Vincent Peter Sica, Timothy R Baker
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Abstract
A method of inhibiting the conversion of choline to trimethylamine (TMA) and lowering TMAO in an individual by providing a composition comprising (2-hydroxyethyl) dimethylsulfonium with a counterion wherein the counterion is selected from chloride, bromide or iodide.
Claims11
A method of inhibiting the conversion of choline to trimethylamine (TMA) by a bacterium comprising:
- providing
- wherein X− is chloride, bromide, iodide or a pharmaceutically acceptable anion,
- and including any acceptable salts or solvates thereof;
- wherein the (2-hydroxyethyl) dimethylsulfoxonium is provided in an amount effective to inhibit formation of trimethylamine (TMA) from choline.
A method of improving a condition associated with the conversion of choline to trimethylamine (TMA) in an individual comprising administering to the individual (2-hydroxyethyl) dimethylsulfoxonium;
- wherein the (2-hydroxyethyl) dimethylsulfoxonium is administered in an amount effective to treat or prevent the disease or condition associated with choline-related trimethylamine (TMA) in the individual.
A method of inhibiting the conversion of choline to trimethylamine (TMA) and reducing TMAO level in an individual comprising administering to the individual a composition comprising (2-hydroxyethyl) dimethylsulfoxonium;
- wherein the composition is administered in an amount effective to inhibit formation of trimethylamine (TMA) from choline in the individual.
Dependencies are inferred from the claim text.