Cationic materials and formulations for drug delivery
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsOmid Farokhzad, Jun Wu, Lili Zhao
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Abstract
Cationic polymers are provided for delivering anionic active agents, preferably in the form or nanoparticles and other nanostructures. The polymer can be a polycation homopolymer or a copolymer containing a polycation block. The polycations and polycation containing polymers can contain dicarboxylic acid ester units and units of (α-amino acid)-α,ω-alkylene diester units. The nanoparticles can contain high loadings of anionic active agents, with sustained release of the active agents. Methods of making the polycations and polycation containing polymers are provided. Methods of making the nanoparticles and formulating them for administration to an individual in need thereof are also provided.
Claims25
A particle comprising:
- (a) one or more cationic polymer cores comprising a block copolymer comprising a polycation block and a biodegradable polymer block;
- and
- (b) a layer of anionic active agents encapsulating the one or more cationic polymer cores.
A polymer comprising cationic units having the structure
- wherein R1 is selected from the group consisting of linear and branched alkyl and substituted alkyl, alkenyl, or alkylene oxide groups containing from 2 to 20 carbon atoms;
- wherein R2 is selected from the group consisting of aliphatic amines, cycloaliphatic amines, heterocyclic amines, and aromatic amines containing from 1 to 12 carbon atoms;
- and
- wherein n is an integer between 1 and 1,000.
Dependencies are inferred from the claim text.