Transcatheter pulmonic regenerative valve
AssigneeEdwards Lifesciences Corporation
InventorsHao Shang, Louis A. Campbell
Life of this patent
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Abstract
Artificial heart valves, their manufacture, and methods of use are described. Generally, artificial heart valves can be deployed to replace or supplement defective heart valves in a patient. These artificial heart valves can comprise a frame with an inner skirt and leaflets. These inner skirt and leaflets can be generated from regenerative tissue to allow integration of the tissue with the body of a patient, while the frame can be generated from bioabsorb able material to allow dissolution of the frame over time. This combination of materials may allow for the artificial valve to grow with a patient and avoid costly and potentially dangerous replacement for patients receiving artificial valves.
Claims87
An implantable artificial heart valve comprising:
- a frame having a longitudinal axis extending between an inflow end of the frame and an outflow end of the frame, the inflow end of the frame being configured to receive antegrade blood flowing into the prosthetic valve when implanted;
- a leaflet structure positioned within the frame and constructed of a first regenerative tissue;
- and
- an inner skirt positioned around an inner surface of the frame and extending along the longitudinal axis, wherein the inner skirt is constructed of a second regenerative tissue.
An assembly for implanting an artificial heart valve in a patient's body comprising:
- a delivery apparatus comprising an elongated shaft;
- and
- a radially expandable artificial heart valve adapted to be mounted on the shaft in a radially collapsed configuration for delivery into the body, the prosthetic heart valve comprising a frame having an inflow end portion defining an inflow end of the frame that is configured to receive antegrade blood flow into the artificial heart valve when implanted, and the frame also having an outflow end portion defining an outflow end of the frame opposite the inflow end of the frame, the prosthetic heart valve also comprising a leaflet structure positioned within the frame, an inner skirt positioned along an inner surface of the frame;
- wherein the leaflet structure is constructed of a regenerative tissue, and the inner skirt is constructed of a second regenerative tissue.
A method of implanting an artificial heart valve using a catheter comprising:
- accessing the vascular system of a patient;
- advancing a radially expandable artificial heart valve to the pulmonary artery of the patient, wherein the artificial heart valve is in a radially collapsed configuration and comprises a frame having an inflow end portion defining an inflow end of the frame that is configured to receive antegrade blood flow into the artificial heart valve when implanted, and the frame also having an outflow end portion defining an outflow end of the frame opposite the inflow end of the frame, the prosthetic heart valve also comprising a leaflet structure positioned within the frame, an inner skirt positioned along an inner surface of the frame, wherein the leaflet structure is constructed of a regenerative tissue, and the inner skirt is constructed of a second regenerative tissue, and wherein the artificial heart valve is mounted on a delivery apparatus;
- and
- delivering the radially expandable artificial heart valve to the pulmonary artery of the patient.
A method of treating a patient for a valvular disease comprising:
- identifying a valvular disease in a patient;
- and
- implanting an artificial heart valve into a blood vessel of the patient, wherein the artificial heart valve comprises a frame having an inflow end portion defining an inflow end of the frame that is configured to receive antegrade blood flow into the artificial heart valve when implanted, and the frame also having an outflow end portion defining an outflow end of the frame opposite the inflow end of the frame, the prosthetic heart valve also comprising a leaflet structure positioned within the frame, an inner skirt positioned along an inner surface of the frame, wherein the leaflet structure is constructed of a first regenerative tissue, and the inner skirt is constructed of a second regenerative tissue.
Dependencies are inferred from the claim text.