Apparatus and Methods for Irradiating Organ Perfusates

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A method for rescuing donor organs obtained from an individual suffering from an infection, for use in transplantation into a recipient, where said infection would have disqualified said organ for use in transplantation, said method comprising:

• a. perfusing said donor organ with a hypothermic perfusion solution in an ex-vivo system for a first period of time, where said period of time is determined on the basis that the individual was not infected to produce a perfusate;
• and
• b. irradiating said perfusate for a second period of time, applied concurrently with the perfusion of said organ, wherein said second period of time being no greater than 9 hours.

A method of using an infected organ for transplanting, the method comprising

• perfusing the infected organ with a hypothermic perfusion solution by ex vivo perfusion (EVP) to provide a perfusate;
• irradiating the perfusate with a light therapy selected from UVC or PDT for at least 2 hours;
• transplanting the perfused and light therapy treated organ into a subject.

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The method of claim 30, the apparatus further comprising safety sensors for detecting when the upper unit is moved up and/or down on top of the lower unit, such that the sensors detect when the irradiator is open and/or closed and for preventing it from being inadvertently activated while the upper unit is open, optionally wherein the safety sensors comprise sensing plates positioned on the lower and upper units, such that the sensors detect when the upper unit is moved on top of the lower unit.

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