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US 2020/0138013 A1Published application
Polymer based transplant preservation solution
AssigneesJayachandrar Kizhakkedathu, Caigan Du, Donald Brooks, Christopher Nguan
InventorsJayachandran KIZHAKKEDATHU, Caigan DU, Donald BROOKS, Christopher NGUAN
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Abstract
Provided are transplant preservation solutions comprising a polyglycerol wherein the polyglycerol is of a molecular weight between about 0.15 kDa and about 3.99 kDa, methods and uses thereof as well as kits providing said transplant preservation solutions.
Claims25
1-65. (canceled)
A method of treating a donor organ, the method comprising:
- administering a transplant preservation solution to a donor organ, the transplant preservation solution comprising at least one hyperbranched or dendritic polyglycerol in a UW-type solution, wherein the UW-type solution comprising lactobionic acid, potassium hydroxide, potassium dihydrogen phosphate, magnesium sulfate, adenosine, glutathione and allopurinol, wherein the at least one hyperbranched or dendritic polyglycerol has a molecular weight between 0.48 kDa and 3.00 kDa, and wherein the UW-type solution does not comprise raffinose or hydroxyethyl starch.
A method of treating a donor organ to reduce the damaging effects of cold ischemia and warm reperfusion on organ function, the method comprising:
- procuring a donor organ from a first patient;
- administering a transplant preservation solution to the donor organ, the transplant preservation solution comprising at least one hyperbranched or dendritic polyglycerol in a UW-type solution, wherein the UW-type solution comprising lactobionic acid, potassium hydroxide, potassium dihydrogen phosphate, magnesium sulfate, adenosine, glutathione and allopurinol, wherein the at least one hyperbranched or dendritic polyglycerol has a molecular weight between 0.48 kDa and 3.00 kDa, and wherein the UW-type solution does not comprise raffinose or hydroxyethyl starch;
- transporting the donor organ ex-vivo while being maintained in the transplant preservation solution;
- and
- transplanting the donor organ.
2 more elements
Dependencies are inferred from the claim text.