Porcine reproductive and respiratory syndrome virus resistant animals
AssigneeThe Curators of the University of Missouri
InventorsRandall S. Prather, Kevin D. Wells, Kristin M. Whitworth
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Abstract
The present invention generally relates to genetically modified swine wherein at least one allele of a SIGLEC1 gene has been inactivated and/or at least one allele of a CD163 gene has been inactivated. Genetically modified swine having both alleles of the SIGLEC1 gene and/or both alleles CD163 gene inactivated are resistant to porcine reproductive and respiratory syndrome virus (PRRSV). Methods for producing such transgenic swine are also provided.
Claims21
1-49. (canceled)
A genetically modified swine comprising an alteration in a CD163 gene sequence, wherein the alteration comprises an alteration in a portion of the CD163 gene sequence that encodes the SRCR5 domain of the CD163 protein.
Dependencies are inferred from the claim text.