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US 2020/0124508 A1Published application
Sample filtration device
AssigneeSplitrx LLC
InventorEstevan MENDOZA
Life of this patent
Estimating the term…
Abstract
Sample filtration devices are provided. The devices can comprise a filter membrane positioned between an input and output substrate and joined using an adhesive layer. The filter assembly can be used with various sample collection and dispensing devices, such as a flexible container, a bulb pipette, a micropipette, etc. Applying pressure to the filter assembly, e.g., using a flexible container, a bulb pipette or a micropipette can force the fluid through the filter membrane and onto a test strip or cartridge.
Claims179
A sample filtration device for processing a sample, comprising
- a flexible container;
- a cap configured to seal to the flexible container, the cap comprising
- one or more inlet holes in fluid communication with the flexible container;
- an asymmetric filter in fluid communication with the one or more inlet holes and configured to filter the sample into a filtrate;
- a support component comprising one or more channels in fluid communication with the filtrate from the asymmetric filter;
- an adhesive layer configured to join the filter to the cap or the support component;
- and
- an outlet in fluid communication with the one or more channels.
5 more elements
The sample filtration device wherein, wherein a surface of the support component that joins the adhesive layer is substantially flat.
A method of filtering a sample, further comprising one or more additional filters.
- providing a sample filtration device comprising a flexible container and a cap configured to seal to the flexible container;
- placing a sample fluid into the flexible container;
- and
- squeezing the flexible container, thereby pushing the sample fluid through one or more inlet holes in the cap, through an asymmetric filter to create a filtrate, and pushing the filtrate through one or more channels to an outlet.
1 more element
A method of manufacturing a sample filtration device, comprising
- providing a first substrate comprising an inlet hole;
- providing an asymmetric filter in fluid communication with the inlet hole and configured to filter the sample into a filtrate;
- providing a second substrate comprising one or more channels in fluid communication with the filtrate from the filter and in fluid communication with an outlet hole;
- and
- providing an adhesive layer comprising a central cutout smaller than a size of the asymmetric filter, the adhesive layer configured to join the asymmetric filter to the first substrate or the second substrate.
2 more elements
A sample filtration device comprising
- a flexible connector comprising a funnel shaped opening leading to a tube portion;
- an input substrate comprising an inlet contracting hole in fluid connection with the tube portion;
- an asymmetric filter membrane in fluid communication with the inlet contracting hole and configured to filter the sample into a filtrate;
- an adhesive layer configured to join to the asymmetric filter membrane, the adhesive layer comprising a central cutout configured to expose a central portion of the filter membrane;
- and
- an output substrate comprising one or more channels in fluid communication with the filtrate from the asymmetric filter, the one or more channels in fluid communication with an outlet of the output substrate.
3 more elements
A method of filtering a sample,
- providing a sample filtration device comprising a flexible connector comprising a funnel shaped opening leading to a tube portion;
- the tube portion in fluid communication with an inlet of an input substrate, the inlet in fluid communication with an asymmetric filter membrane, the asymmetric filter membrane connected to an adhesive layer, and an output substrate comprising one or more channels configured to receive filtrate from the filter membrane and comprising an outlet;
- attaching a sample collection or dispensing device to the flexible container;
- and
- applying pressure to the sample collection or dispensing device, thereby pushing the sample fluid through the asymmetric filter to create a filtrate, and pushing the filtrate through one or more channels to the outlet.
2 more elements
A sample filtration device comprising
- an input substrate comprising an inlet hole;
- an asymmetric filter membrane in fluid communication with the inlet hole and configured to filter the sample into a filtrate;
- an adhesive layer configured to join to the asymmetric filter membrane, the adhesive layer comprising a central cutout configured to expose a central portion of the filter membrane;
- and
- an output substrate comprising one or more channels in fluid communication with the filtrate from the asymmetric filter, the one or more channels in fluid communication with an outlet of the output substrate.
2 more elements
A method of filtering a sample, comprising
- providing a sample filtration device comprising an input substrate comprising an inlet hole;
- an asymmetric filter membrane in fluid communication with the inlet hole and configured to filter the sample into a filtrate;
- an adhesive layer configured to join to the asymmetric filter membrane, the adhesive layer comprising a central cutout configured to expose a central portion of the filter membrane;
- and an output substrate comprising one or more channels in fluid communication with the filtrate from the asymmetric filter, the one or more channels in fluid communication with an outlet of the output substrate;
- connecting a sample collecting or dispensing device to the inlet hole;
- and
- activating the sample collecting or dispensing device to drive the sample through the filter membrane.
4 more elements
Dependencies are inferred from the claim text.