Recombinant oncolytic viruses for treatment of metastatic cancers
AssigneeEntos Pharmaceuticals Inc.
InventorsRoy Duncan, Chungen Pan
Life of this patent
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Abstract
Disclosed are recombinant oncolytic viruses that express one or more reovirus fusion-associated small transmembrane FAST) proteins and uses thereof. The oncolytic activity of the recombinant oncolytic viruses expressing FAST proteins can be used to treat primary and metastatic cancers, especially from breast and colon cancers.
Claims24
A recombinant oncolytic virus that expresses one or more reovirus fusion-associated small transmembrane (FAST) proteins.
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A recombinant oncolytic virus that expresses one or more non-enveloped viral membrane fusion protein, the one or more non-enveloped viral membrane fusion protein comprising:
- a transmembrane (TM) domain,
- a cytosolic, membrane-proximal cluster of three or more basic amino acids,
- an at least one post-translational fatty acid modification, and
- an N-terminal ectodomain.
Dependencies are inferred from the claim text.